Whoa! Sorry about the long delay, folks. In case you missed Podcast #45, with Ray DePaulo, the Chair of Psychiatry at Johns Hopkins, we talked about cosmetic psychopharmacology -- taking psychotropic medications to improve one's mental performance better than one's normal baseline. We then had two related posts, I Forgot (what happens when memory does not work well) and Now I Remember (when people remember too well, such as traumatic memories and PTSD).
June 1, 2008: #46 Fugetaboutit!
- PTSD. A Psychiatrist Who Learned From Veterans commented that "A really towering paper in the Posttraumatic Stress Disorder literature deals with the excessive stickiness of memory in PTSD. The data comprises case reports of the month long use of Cortisol (Cortef) 10 mg a day, this is a low dose of glucocorticoid, by Amanda Aerni. R Greene at the Dallas VA has a nice paper using rats in a related paper; impressive statistics in the latter." These papers are discussed in the podcast, and mentioned in more detail below.
- Cortisol for PTSD. Amanda Aerni, et al., published "Low-Dose Cortisol for Symptoms of Posttraumatic Stress Disorder" in the August 2004 American Journal of Psychiatry. This was a 3-month observation study on three people with chronic PTSD, using a low-dose of cortisol in a double-blind, placebo-controlled manner. They found "cortisol-related reductions of at least 38% in one of the daily rated symptoms of traumatic memories, as assessed by self-administered rating scales."
- Memory "Erasure". Wen-Hui Cai, et al., published "Postreactivation Glucocorticoids Impair Recall of Established Fear Memory" in the September 2006 Journal of Neuroscience. This study exposed mice to a trauma (loud noise). After developing mousie PTSD, exposure to glucocorticoids at some later time after the traumatic memory is being triggered caused the fear response to be much less.
- More PTSD Talk. Pink Freud commented that "On the surface, I find the thought of preventing the formation of memories (traumatic or otherwise) to be repugnant. It's experiencing, working through, and ultimately making meaning of what life deals us that defines the human condition." Here follows lots of discussion about what is a "trauma" (such as being hit by a flying, flaming toilet seat [Youtube] from the space shuttle as in the show Dead Like Me, or being tasered at a political event [Don't tase me, bro]) and how some people are at increased risk for developing PTSD given similar traumas. Also, discussion about reducing the strength of the connection between a traumatic memory and a pathologic fear response.
- Dinah's Flomax (tamulosin). Dinah discusses the discrepancy between the focus on benign prostate conditions and other more serious ones.
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