Friday, May 16, 2008

HAPPY BIRTHDAY, CLINKSHRINK!!!!


I'm told the theme is "fungus." I'm working on it. Love, Dinah

14 comments:

Anonymous said...

Happy Birthday Clink Shrink.
May God bless you!

Anonymous said...

Happy Birtday Clink! (--Midwife With a Knife)

Dr. A said...

Happy Happy Birthday!

Clink said...

Thanks everybody! I think I should share my horoscope for today:


Taurus (April 20-May 20): You're a bit of a provocateur. Sometimes it's reassuring when others have a big reaction to you. It means that you're really being heard.

Provocative? Who, me?

Catherine said...

Thematic joke:

What did the greeter say to the mushroom when he went to the party?




(you look like a "fun guy")


Happy Birthday.

Therapy Patient said...

Happy Birthday!

NeoNurseChic said...

Happy Birthday! Hope it was a good one! :)

Take care,
Carrie :)

Dr. Pink Freud said...

For your birthday; a list of the my favorite anagrams for "psychiatrist."

I sit spy chart
Psych, art it is
At psych I stir

Frohliche Geburtstag!

ladyak47 said...

FUNGUS????

Rach said...

I don't get the mushrooms, but I hope they were enjoyed!

Happy birthday.

jcat said...

Happy (belated)birthday, Clink!

Dr. Pink Freud said...

Just an abstract, but it's the closest to the subject matter I could get.

Volume 272, Number 3, Issue of January 17, 1997 pp. 1514-1521
©1997 by The American Society for Biochemistry and Molecular Biology, Inc.

Fungal Galectins, Sequence and Specificity of Two Isolectins from Coprinus cinereus

(Received for publication,
September 20, 1996, and in revised form, October 23, 1996)
Douglas N. W. Cooper Dagger , Robert P. Boulianne ¶ , Stacy Charlton ¶ , Eleanor M. Farrell Dagger , Anatol Sucher Dagger and Benjamin C. Lu ¶

From the Dagger Departments of Anatomy and Psychiatry, Langley Porter Psychiatric Institute, Center for Neurobiology and Psychiatry, University of California, San Francisco, California 94143-0984 and the ¶ Department of Molecular Biology and Genetics, University of Guelph, Ontario, N1G 2W1 Canada

Galectins are members of a genetically related family of beta -galactoside-binding lectins. At least eight distinct mammalian galectins have been identified. More distantly related, but still conserving amino acid residues critical for carbohydrate-binding, are galectins in chicken, eel, frog, nematode, and sponge. Here we report that galectins are also expressed in a species of fungus, the inky cap mushroom, Coprinus cinereus. Two dimeric galectins are expressed during fruiting body formation which are 83% identical to each other in amino acid sequence and conserve all key residues shared by members of the galectin family. Unlike most galectins, these have no N-terminal post-translational modification and no cysteine residues. We expressed one of these as a recombinant protein and studied its carbohydrate-binding specificity using a novel nonradioactive assay. Binding specificity has been well studied for a number of other galectins, and like many of these, the recombinant C. cinereus galectin shows particular affinity for blood group A structures. These results demonstrate not only that the galectin gene family is evolutionarily much older than previously realized but also that fine specificity for complex saccharide structures has been conserved. Such conservation implies that galectins evolved to perform very basic cellular functions, presumably by interaction with glycoconjugates bearing complex lactoside carbohydrates resembling blood group A.

ClinkShrink said...

Thanks again everybody!

Pink: Extra credit for the research-related mushroom reference.

And for everybody wondering what's up with me and mushrooms, it's a reference to my post from last year Call Of The Wild.

Sarebear said...
This comment has been removed by the author.